Significant association between clinical characteristics and changes in peripheral immuno-phenotype in large vessel vasculitis
Identifieur interne : 000844 ( Main/Exploration ); précédent : 000843; suivant : 000845Significant association between clinical characteristics and changes in peripheral immuno-phenotype in large vessel vasculitis
Auteurs : Kotaro Matsumoto [Japon] ; Katsuya Suzuki [Japon] ; Keiko Yoshimoto [Japon] ; Noriyasu Seki ; Hideto Tsujimoto ; Kenji Chiba ; Tsutomu Takeuchi [Japon]Source :
- Arthritis Research & Therapy [ 1478-6354 ] ; 2019.
Abstract
Large vessel vasculitis (LVV) is a type of vasculitis characterized by granulomatous inflammation of medium- and large-sized arteries. Clinical assessment of acute phase reactants has been conventionally used to diagnose and monitor diseases; however, accurate assessment of vascular disease activity status can be difficult. In this study, we investigated comprehensive immuno-phenotyping to explore useful biomarkers associated with clinical characteristics.
Consecutive patients with newly diagnosed LVV who visited our institution between May 2016 and May 2019 were enrolled. The number of circulating T cells, B cells, natural killer cells, dendritic cells, monocytes, and granulocytes was examined and chronologically followed. Baseline and time-course changes in immuno-phenotyping associated with disease activity were assessed.
Comprehensive immuno-phenotyping data from 90 samples from each of 20 patients with LVV were compared with those from healthy controls (HCs). The number of helper T (Th), follicular helper T (Tfh), CD8+ T, CD14++ CD16+ monocytes, and neutrophils were higher in patients with giant cell arteritis (GCA) and/or Takayasu arteritis (TAK) than in HCs. Among them, the number of CD8+ T and CD8+ Tem were higher in patients with TAK than in GCA. Notably, memory CD4+ and CD8+ T cells in patients with TAK remained high even in the remission phase. Further analysis revealed that the number of Th1, Th17, and Tfh cells was associated with disease relapse in GCA and TAK and that the number of CD8+ T cells was associated with relapse in TAK. Th1, Th17, and Tfh cells decreased after treatment with biologic agents, while CD8+ T cells did not.
Our results from peripheral immuno-phenotyping analysis indicate that the numbers of Th and Tfh cells changed along with the disease condition in both GCA and TAK, while that of CD8+ T cells did not, especially in TAK. Treatment with biologic agents decreased the proportion of Th and Tfh cells, but not CD8+ T cells, in the patients. Chronological immuno-phenotyping data explained the difference in therapeutic response, such as reactivities against biologics, between GCA and TAK.
Url:
DOI: 10.1186/s13075-019-2068-7
PubMed: 31888748
PubMed Central: 6937853
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000218
- to stream Pmc, to step Curation: 000218
- to stream Pmc, to step Checkpoint: 000583
- to stream Ncbi, to step Merge: 002740
- to stream Ncbi, to step Curation: 002740
- to stream Ncbi, to step Checkpoint: 002740
- to stream Main, to step Merge: 000844
- to stream Main, to step Curation: 000844
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Significant association between clinical characteristics and changes in peripheral immuno-phenotype in large vessel vasculitis</title><author><name sortKey="Matsumoto, Kotaro" sort="Matsumoto, Kotaro" uniqKey="Matsumoto K" first="Kotaro" last="Matsumoto">Kotaro Matsumoto</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9959</institution-id><institution-id institution-id-type="GRID">grid.26091.3c</institution-id><institution>Division of Rheumatology, Department of Internal Medicine,</institution><institution>Keio University School of Medicine,</institution></institution-wrap>35 Shinanomachi, Shinjuku-ku, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>35 Shinanomachi, Shinjuku-ku, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Suzuki, Katsuya" sort="Suzuki, Katsuya" uniqKey="Suzuki K" first="Katsuya" last="Suzuki">Katsuya Suzuki</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9959</institution-id><institution-id institution-id-type="GRID">grid.26091.3c</institution-id><institution>Division of Rheumatology, Department of Internal Medicine,</institution><institution>Keio University School of Medicine,</institution></institution-wrap>35 Shinanomachi, Shinjuku-ku, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>35 Shinanomachi, Shinjuku-ku, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Yoshimoto, Keiko" sort="Yoshimoto, Keiko" uniqKey="Yoshimoto K" first="Keiko" last="Yoshimoto">Keiko Yoshimoto</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9959</institution-id><institution-id institution-id-type="GRID">grid.26091.3c</institution-id><institution>Division of Rheumatology, Department of Internal Medicine,</institution><institution>Keio University School of Medicine,</institution></institution-wrap>35 Shinanomachi, Shinjuku-ku, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>35 Shinanomachi, Shinjuku-ku, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0633 2119</institution-id><institution-id institution-id-type="GRID">grid.412096.8</institution-id><institution>Clinical and Translational Research Center,</institution><institution>Keio University Hospital,</institution></institution-wrap>35 Shinanomachi, Shinjuku-ku, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>35 Shinanomachi, Shinjuku-ku, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Seki, Noriyasu" sort="Seki, Noriyasu" uniqKey="Seki N" first="Noriyasu" last="Seki">Noriyasu Seki</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1808 2657</institution-id><institution-id institution-id-type="GRID">grid.418306.8</institution-id><institution>Mitsubishi Tanabe Pharma Corporation,</institution></institution-wrap>1000, Kamoshida-cho, Aoba-ku, Yokohama, Kanagawa Japan</nlm:aff><wicri:noCountry code="subfield">Kanagawa Japan</wicri:noCountry></affiliation></author><author><name sortKey="Tsujimoto, Hideto" sort="Tsujimoto, Hideto" uniqKey="Tsujimoto H" first="Hideto" last="Tsujimoto">Hideto Tsujimoto</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1808 2657</institution-id><institution-id institution-id-type="GRID">grid.418306.8</institution-id><institution>Mitsubishi Tanabe Pharma Corporation,</institution></institution-wrap>1000, Kamoshida-cho, Aoba-ku, Yokohama, Kanagawa Japan</nlm:aff><wicri:noCountry code="subfield">Kanagawa Japan</wicri:noCountry></affiliation></author><author><name sortKey="Chiba, Kenji" sort="Chiba, Kenji" uniqKey="Chiba K" first="Kenji" last="Chiba">Kenji Chiba</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1808 2657</institution-id><institution-id institution-id-type="GRID">grid.418306.8</institution-id><institution>Mitsubishi Tanabe Pharma Corporation,</institution></institution-wrap>1000, Kamoshida-cho, Aoba-ku, Yokohama, Kanagawa Japan</nlm:aff><wicri:noCountry code="subfield">Kanagawa Japan</wicri:noCountry></affiliation></author><author><name sortKey="Takeuchi, Tsutomu" sort="Takeuchi, Tsutomu" uniqKey="Takeuchi T" first="Tsutomu" last="Takeuchi">Tsutomu Takeuchi</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9959</institution-id><institution-id institution-id-type="GRID">grid.26091.3c</institution-id><institution>Division of Rheumatology, Department of Internal Medicine,</institution><institution>Keio University School of Medicine,</institution></institution-wrap>35 Shinanomachi, Shinjuku-ku, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>35 Shinanomachi, Shinjuku-ku, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31888748</idno><idno type="pmc">6937853</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937853</idno><idno type="RBID">PMC:6937853</idno><idno type="doi">10.1186/s13075-019-2068-7</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000218</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000218</idno><idno type="wicri:Area/Pmc/Curation">000218</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000218</idno><idno type="wicri:Area/Pmc/Checkpoint">000583</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000583</idno><idno type="wicri:Area/Ncbi/Merge">002740</idno><idno type="wicri:Area/Ncbi/Curation">002740</idno><idno type="wicri:Area/Ncbi/Checkpoint">002740</idno><idno type="wicri:doubleKey">1478-6354:2019:Matsumoto K:significant:association:between</idno><idno type="wicri:Area/Main/Merge">000844</idno><idno type="wicri:Area/Main/Curation">000844</idno><idno type="wicri:Area/Main/Exploration">000844</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Significant association between clinical characteristics and changes in peripheral immuno-phenotype in large vessel vasculitis</title><author><name sortKey="Matsumoto, Kotaro" sort="Matsumoto, Kotaro" uniqKey="Matsumoto K" first="Kotaro" last="Matsumoto">Kotaro Matsumoto</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9959</institution-id><institution-id institution-id-type="GRID">grid.26091.3c</institution-id><institution>Division of Rheumatology, Department of Internal Medicine,</institution><institution>Keio University School of Medicine,</institution></institution-wrap>35 Shinanomachi, Shinjuku-ku, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>35 Shinanomachi, Shinjuku-ku, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Suzuki, Katsuya" sort="Suzuki, Katsuya" uniqKey="Suzuki K" first="Katsuya" last="Suzuki">Katsuya Suzuki</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9959</institution-id><institution-id institution-id-type="GRID">grid.26091.3c</institution-id><institution>Division of Rheumatology, Department of Internal Medicine,</institution><institution>Keio University School of Medicine,</institution></institution-wrap>35 Shinanomachi, Shinjuku-ku, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>35 Shinanomachi, Shinjuku-ku, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Yoshimoto, Keiko" sort="Yoshimoto, Keiko" uniqKey="Yoshimoto K" first="Keiko" last="Yoshimoto">Keiko Yoshimoto</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9959</institution-id><institution-id institution-id-type="GRID">grid.26091.3c</institution-id><institution>Division of Rheumatology, Department of Internal Medicine,</institution><institution>Keio University School of Medicine,</institution></institution-wrap>35 Shinanomachi, Shinjuku-ku, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>35 Shinanomachi, Shinjuku-ku, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0633 2119</institution-id><institution-id institution-id-type="GRID">grid.412096.8</institution-id><institution>Clinical and Translational Research Center,</institution><institution>Keio University Hospital,</institution></institution-wrap>35 Shinanomachi, Shinjuku-ku, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>35 Shinanomachi, Shinjuku-ku, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Seki, Noriyasu" sort="Seki, Noriyasu" uniqKey="Seki N" first="Noriyasu" last="Seki">Noriyasu Seki</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1808 2657</institution-id><institution-id institution-id-type="GRID">grid.418306.8</institution-id><institution>Mitsubishi Tanabe Pharma Corporation,</institution></institution-wrap>1000, Kamoshida-cho, Aoba-ku, Yokohama, Kanagawa Japan</nlm:aff><wicri:noCountry code="subfield">Kanagawa Japan</wicri:noCountry></affiliation></author><author><name sortKey="Tsujimoto, Hideto" sort="Tsujimoto, Hideto" uniqKey="Tsujimoto H" first="Hideto" last="Tsujimoto">Hideto Tsujimoto</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1808 2657</institution-id><institution-id institution-id-type="GRID">grid.418306.8</institution-id><institution>Mitsubishi Tanabe Pharma Corporation,</institution></institution-wrap>1000, Kamoshida-cho, Aoba-ku, Yokohama, Kanagawa Japan</nlm:aff><wicri:noCountry code="subfield">Kanagawa Japan</wicri:noCountry></affiliation></author><author><name sortKey="Chiba, Kenji" sort="Chiba, Kenji" uniqKey="Chiba K" first="Kenji" last="Chiba">Kenji Chiba</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1808 2657</institution-id><institution-id institution-id-type="GRID">grid.418306.8</institution-id><institution>Mitsubishi Tanabe Pharma Corporation,</institution></institution-wrap>1000, Kamoshida-cho, Aoba-ku, Yokohama, Kanagawa Japan</nlm:aff><wicri:noCountry code="subfield">Kanagawa Japan</wicri:noCountry></affiliation></author><author><name sortKey="Takeuchi, Tsutomu" sort="Takeuchi, Tsutomu" uniqKey="Takeuchi T" first="Tsutomu" last="Takeuchi">Tsutomu Takeuchi</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9959</institution-id><institution-id institution-id-type="GRID">grid.26091.3c</institution-id><institution>Division of Rheumatology, Department of Internal Medicine,</institution><institution>Keio University School of Medicine,</institution></institution-wrap>35 Shinanomachi, Shinjuku-ku, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>35 Shinanomachi, Shinjuku-ku, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author></analytic><series><title level="j">Arthritis Research & Therapy</title><idno type="ISSN">1478-6354</idno><idno type="eISSN">1478-6362</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">Large vessel vasculitis (LVV) is a type of vasculitis characterized by granulomatous inflammation of medium- and large-sized arteries. Clinical assessment of acute phase reactants has been conventionally used to diagnose and monitor diseases; however, accurate assessment of vascular disease activity status can be difficult. In this study, we investigated comprehensive immuno-phenotyping to explore useful biomarkers associated with clinical characteristics.</p></sec><sec><title>Methods</title><p id="Par2">Consecutive patients with newly diagnosed LVV who visited our institution between May 2016 and May 2019 were enrolled. The number of circulating T cells, B cells, natural killer cells, dendritic cells, monocytes, and granulocytes was examined and chronologically followed. Baseline and time-course changes in immuno-phenotyping associated with disease activity were assessed.</p></sec><sec><title>Results</title><p id="Par3">Comprehensive immuno-phenotyping data from 90 samples from each of 20 patients with LVV were compared with those from healthy controls (HCs). The number of helper T (Th), follicular helper T (Tfh), CD8<sup>+</sup> T, CD14<sup>++</sup> CD16<sup>+</sup> monocytes, and neutrophils were higher in patients with giant cell arteritis (GCA) and/or Takayasu arteritis (TAK) than in HCs. Among them, the number of CD8<sup>+</sup> T and CD8<sup>+</sup> Tem were higher in patients with TAK than in GCA. Notably, memory CD4<sup>+</sup> and CD8<sup>+</sup> T cells in patients with TAK remained high even in the remission phase. Further analysis revealed that the number of Th1, Th17, and Tfh cells was associated with disease relapse in GCA and TAK and that the number of CD8<sup>+</sup> T cells was associated with relapse in TAK. Th1, Th17, and Tfh cells decreased after treatment with biologic agents, while CD8<sup>+</sup> T cells did not.</p></sec><sec><title>Conclusions</title><p id="Par4">Our results from peripheral immuno-phenotyping analysis indicate that the numbers of Th and Tfh cells changed along with the disease condition in both GCA and TAK, while that of CD8<sup>+</sup> T cells did not, especially in TAK. Treatment with biologic agents decreased the proportion of Th and Tfh cells, but not CD8<sup>+</sup> T cells, in the patients. Chronological immuno-phenotyping data explained the difference in therapeutic response, such as reactivities against biologics, between GCA and TAK.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Salvarani, C" uniqKey="Salvarani C">C Salvarani</name></author><author><name sortKey="Cantini, F" uniqKey="Cantini F">F Cantini</name></author><author><name sortKey="Hunder, Gg" uniqKey="Hunder G">GG Hunder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gonzalez Gay, Ma" uniqKey="Gonzalez Gay M">MA Gonzalez-Gay</name></author><author><name sortKey="Vazquez Rodriguez, Tr" uniqKey="Vazquez Rodriguez T">TR Vazquez-Rodriguez</name></author><author><name sortKey="Lopez Diaz, Mj" uniqKey="Lopez Diaz M">MJ Lopez-Diaz</name></author><author><name sortKey="Miranda Filloy, Ja" uniqKey="Miranda Filloy J">JA Miranda-Filloy</name></author><author><name sortKey="Gonzalez Juanatey, C" uniqKey="Gonzalez Juanatey C">C Gonzalez-Juanatey</name></author><author><name sortKey="Martin, J" uniqKey="Martin J">J Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grayson, Pc" uniqKey="Grayson P">PC Grayson</name></author><author><name sortKey="Maksimowicz Mckinnon, K" uniqKey="Maksimowicz Mckinnon K">K Maksimowicz-McKinnon</name></author><author><name sortKey="Clark, Tm" uniqKey="Clark T">TM Clark</name></author><author><name sortKey="Tomasson, G" uniqKey="Tomasson G">G Tomasson</name></author><author><name sortKey="Cuthbertson, D" uniqKey="Cuthbertson D">D Cuthbertson</name></author><author><name sortKey="Carette, S" uniqKey="Carette S">S Carette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jennette, Jc" uniqKey="Jennette J">JC Jennette</name></author><author><name sortKey="Falk, Rj" uniqKey="Falk R">RJ Falk</name></author><author><name sortKey="Bacon, Pa" uniqKey="Bacon P">PA Bacon</name></author><author><name sortKey="Basu, N" uniqKey="Basu N">N Basu</name></author><author><name sortKey="Cid, Mc" uniqKey="Cid M">MC Cid</name></author><author><name sortKey="Ferrario, F" uniqKey="Ferrario F">F Ferrario</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Villiger, Pm" uniqKey="Villiger P">PM Villiger</name></author><author><name sortKey="Adler, S" uniqKey="Adler S">S Adler</name></author><author><name sortKey="Kuchen, S" uniqKey="Kuchen S">S Kuchen</name></author><author><name sortKey="Wermelinger, F" uniqKey="Wermelinger F">F Wermelinger</name></author><author><name sortKey="Dan, D" uniqKey="Dan D">D Dan</name></author><author><name sortKey="Fiege, V" uniqKey="Fiege V">V Fiege</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stone, Jh" uniqKey="Stone J">JH Stone</name></author><author><name sortKey="Tuckwell, K" uniqKey="Tuckwell K">K Tuckwell</name></author><author><name sortKey="Dimonaco, S" uniqKey="Dimonaco S">S Dimonaco</name></author><author><name sortKey="Klearman, M" uniqKey="Klearman M">M Klearman</name></author><author><name sortKey="Aringer, M" uniqKey="Aringer M">M Aringer</name></author><author><name sortKey="Blockmans, D" uniqKey="Blockmans D">D Blockmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakaoka, Y" uniqKey="Nakaoka Y">Y Nakaoka</name></author><author><name sortKey="Isobe, M" uniqKey="Isobe M">M Isobe</name></author><author><name sortKey="Takei, S" uniqKey="Takei S">S Takei</name></author><author><name sortKey="Tanaka, Y" uniqKey="Tanaka Y">Y Tanaka</name></author><author><name sortKey="Ishii, T" uniqKey="Ishii T">T Ishii</name></author><author><name sortKey="Yokota, S" uniqKey="Yokota S">S Yokota</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Molloy, Es" uniqKey="Molloy E">ES Molloy</name></author><author><name sortKey="Langford, Ca" uniqKey="Langford C">CA Langford</name></author><author><name sortKey="Clark, Tm" uniqKey="Clark T">TM Clark</name></author><author><name sortKey="Gota, Ce" uniqKey="Gota C">CE Gota</name></author><author><name sortKey="Hoffman, Gs" uniqKey="Hoffman G">GS Hoffman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gudbrandsson, B" uniqKey="Gudbrandsson B">B Gudbrandsson</name></author><author><name sortKey="Molberg, " uniqKey="Molberg ">Ø Molberg</name></author><author><name sortKey="Palm, " uniqKey="Palm ">Ø Palm</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Langford, Ca" uniqKey="Langford C">CA Langford</name></author><author><name sortKey="Cuthbertson, D" uniqKey="Cuthbertson D">D Cuthbertson</name></author><author><name sortKey="Ytterberg, Sr" uniqKey="Ytterberg S">SR Ytterberg</name></author><author><name sortKey="Khalidi, N" uniqKey="Khalidi N">N Khalidi</name></author><author><name sortKey="Monach, Pa" uniqKey="Monach P">PA Monach</name></author><author><name sortKey="Carette, S" uniqKey="Carette S">S Carette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hunder, Gg" uniqKey="Hunder G">GG Hunder</name></author><author><name sortKey="Bloch, Da" uniqKey="Bloch D">DA Bloch</name></author><author><name sortKey="Michel, Ba" uniqKey="Michel B">BA Michel</name></author><author><name sortKey="Stevens, Mb" uniqKey="Stevens M">MB Stevens</name></author><author><name sortKey="Arend, Wp" uniqKey="Arend W">WP Arend</name></author><author><name sortKey="Calabrese, Lh" uniqKey="Calabrese L">LH Calabrese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kermani, Ta" uniqKey="Kermani T">TA Kermani</name></author><author><name sortKey="Warrington, Kj" uniqKey="Warrington K">KJ Warrington</name></author><author><name sortKey="Cuthbertson, D" uniqKey="Cuthbertson D">D Cuthbertson</name></author><author><name sortKey="Carette, S" uniqKey="Carette S">S Carette</name></author><author><name sortKey="Hoffman, Gs" uniqKey="Hoffman G">GS Hoffman</name></author><author><name sortKey="Khalidi, Na" uniqKey="Khalidi N">NA Khalidi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dasgupta, B" uniqKey="Dasgupta B">B Dasgupta</name></author><author><name sortKey="Cimmino, Ma" uniqKey="Cimmino M">MA Cimmino</name></author><author><name sortKey="Maradit Kremers, H" uniqKey="Maradit Kremers H">H Maradit-Kremers</name></author><author><name sortKey="Schmidt, Wa" uniqKey="Schmidt W">WA Schmidt</name></author><author><name sortKey="Schirmer, M" uniqKey="Schirmer M">M Schirmer</name></author><author><name sortKey="Salvarani, C" uniqKey="Salvarani C">C Salvarani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mowat, C" uniqKey="Mowat C">C Mowat</name></author><author><name sortKey="Cole, A" uniqKey="Cole A">A Cole</name></author><author><name sortKey="Windsor, A" uniqKey="Windsor A">A Windsor</name></author><author><name sortKey="Ahmad, T" uniqKey="Ahmad T">T Ahmad</name></author><author><name sortKey="Arnott, I" uniqKey="Arnott I">I Arnott</name></author><author><name sortKey="Driscoll, R" uniqKey="Driscoll R">R Driscoll</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maecker, Ht" uniqKey="Maecker H">HT Maecker</name></author><author><name sortKey="Mccoy, Jp" uniqKey="Mccoy J">JP McCoy</name></author><author><name sortKey="Nussenblatt, R" uniqKey="Nussenblatt R">R NUssenblatt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Furuta, S" uniqKey="Furuta S">S Furuta</name></author><author><name sortKey="Cousins, C" uniqKey="Cousins C">C Cousins</name></author><author><name sortKey="Chaudhry, A" uniqKey="Chaudhry A">A Chaudhry</name></author><author><name sortKey="Jayne, D" uniqKey="Jayne D">D Jayne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kermani, Ta" uniqKey="Kermani T">TA Kermani</name></author><author><name sortKey="Crowson, Cs" uniqKey="Crowson C">CS Crowson</name></author><author><name sortKey="Muratore, F" uniqKey="Muratore F">F Muratore</name></author><author><name sortKey="Schmidt, J" uniqKey="Schmidt J">J Schmidt</name></author><author><name sortKey="Matteson, El" uniqKey="Matteson E">EL Matteson</name></author><author><name sortKey="Warrington, Kj" uniqKey="Warrington K">KJ Warrington</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deng, J" uniqKey="Deng J">J Deng</name></author><author><name sortKey="Younge, Br" uniqKey="Younge B">BR Younge</name></author><author><name sortKey="Olshen, Ra" uniqKey="Olshen R">RA Olshen</name></author><author><name sortKey="Goronzy, Jj" uniqKey="Goronzy J">JJ Goronzy</name></author><author><name sortKey="Weyand, Cm" uniqKey="Weyand C">CM Weyand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saadoun, D" uniqKey="Saadoun D">D Saadoun</name></author><author><name sortKey="Garrido, M" uniqKey="Garrido M">M Garrido</name></author><author><name sortKey="Comarmond, C" uniqKey="Comarmond C">C Comarmond</name></author><author><name sortKey="Desbois, Ac" uniqKey="Desbois A">AC Desbois</name></author><author><name sortKey="Domont, F" uniqKey="Domont F">F Domont</name></author><author><name sortKey="Savey, L" uniqKey="Savey L">L Savey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kermani, Tanaz A" uniqKey="Kermani T">Tanaz A. Kermani</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Corbera Bellalta, M" uniqKey="Corbera Bellalta M">M Corbera-Bellalta</name></author><author><name sortKey="Planas Rigol, E" uniqKey="Planas Rigol E">E Planas-Rigol</name></author><author><name sortKey="Lozano, E" uniqKey="Lozano E">E Lozano</name></author><author><name sortKey="Terrades Garcia, N" uniqKey="Terrades Garcia N">N Terrades-García</name></author><author><name sortKey="Alba, Ma" uniqKey="Alba M">MA Alba</name></author><author><name sortKey="Prieto Gonzalez, S" uniqKey="Prieto Gonzalez S">S Prieto-González</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Terao, C" uniqKey="Terao C">C Terao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Terao, C" uniqKey="Terao C">C Terao</name></author><author><name sortKey="Yoshifuji, H" uniqKey="Yoshifuji H">H Yoshifuji</name></author><author><name sortKey="Matsumura, T" uniqKey="Matsumura T">T Matsumura</name></author><author><name sortKey="Naruse, Tk" uniqKey="Naruse T">TK Naruse</name></author><author><name sortKey="Ishii, T" uniqKey="Ishii T">T Ishii</name></author><author><name sortKey="Nakaoka, Y" uniqKey="Nakaoka Y">Y Nakaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barrier, J" uniqKey="Barrier J">J Barrier</name></author><author><name sortKey="Bignon, Jd" uniqKey="Bignon J">JD Bignon</name></author><author><name sortKey="Soulillou, Jp" uniqKey="Soulillou J">JP Soulillou</name></author><author><name sortKey="Grolleau, J" uniqKey="Grolleau J">J Grolleau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carmona, Fd" uniqKey="Carmona F">FD Carmona</name></author><author><name sortKey="Gonzalez Gay, Ma" uniqKey="Gonzalez Gay M">MA González-Gay</name></author><author><name sortKey="Martin, J" uniqKey="Martin J">J Martín</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Polachek, A" uniqKey="Polachek A">A Polachek</name></author><author><name sortKey="Pauzner, R" uniqKey="Pauzner R">R Pauzner</name></author><author><name sortKey="Levartovsky, D" uniqKey="Levartovsky D">D Levartovsky</name></author><author><name sortKey="Rosen, G" uniqKey="Rosen G">G Rosen</name></author><author><name sortKey="Nesher, G" uniqKey="Nesher G">G Nesher</name></author><author><name sortKey="Breuer, G" uniqKey="Breuer G">G Breuer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miyabe, C" uniqKey="Miyabe C">C Miyabe</name></author><author><name sortKey="Miyabe, Y" uniqKey="Miyabe Y">Y Miyabe</name></author><author><name sortKey="Strle, K" uniqKey="Strle K">K Strle</name></author><author><name sortKey="Kim, Nd" uniqKey="Kim N">ND Kim</name></author><author><name sortKey="Stone, Jh" uniqKey="Stone J">JH Stone</name></author><author><name sortKey="Luster, Ad" uniqKey="Luster A">AD Luster</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><noCountry><name sortKey="Chiba, Kenji" sort="Chiba, Kenji" uniqKey="Chiba K" first="Kenji" last="Chiba">Kenji Chiba</name><name sortKey="Seki, Noriyasu" sort="Seki, Noriyasu" uniqKey="Seki N" first="Noriyasu" last="Seki">Noriyasu Seki</name><name sortKey="Tsujimoto, Hideto" sort="Tsujimoto, Hideto" uniqKey="Tsujimoto H" first="Hideto" last="Tsujimoto">Hideto Tsujimoto</name></noCountry><country name="Japon"><region name="Région de Kantō"><name sortKey="Matsumoto, Kotaro" sort="Matsumoto, Kotaro" uniqKey="Matsumoto K" first="Kotaro" last="Matsumoto">Kotaro Matsumoto</name></region><name sortKey="Suzuki, Katsuya" sort="Suzuki, Katsuya" uniqKey="Suzuki K" first="Katsuya" last="Suzuki">Katsuya Suzuki</name><name sortKey="Takeuchi, Tsutomu" sort="Takeuchi, Tsutomu" uniqKey="Takeuchi T" first="Tsutomu" last="Takeuchi">Tsutomu Takeuchi</name><name sortKey="Yoshimoto, Keiko" sort="Yoshimoto, Keiko" uniqKey="Yoshimoto K" first="Keiko" last="Yoshimoto">Keiko Yoshimoto</name><name sortKey="Yoshimoto, Keiko" sort="Yoshimoto, Keiko" uniqKey="Yoshimoto K" first="Keiko" last="Yoshimoto">Keiko Yoshimoto</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/TocilizumabV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000844 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000844 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= TocilizumabV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6937853
|texte= Significant association between clinical characteristics and changes in peripheral immuno-phenotype in large vessel vasculitis
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31888748" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a TocilizumabV1
| This area was generated with Dilib version V0.6.34. |  |